Replacement of invariant bZip residues within the basic region of the yeast transcriptional activator GCN4 can change its DNA binding specificity.

Two residues are invariant in all bZip basic regions: asparagine -18 and arginine -10 (we define the first leucine of the leucine zipper of GCN4 as +1). X-ray structures of two specific GCN4-DNA complexes (Ellenberger et al., Cell, 71, 1223-1237, 1992; König & Richmond, J. Mol. Biol., 233, 139-154,...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Suckow, M, Schwamborn, K, Kisters-Woike, B, von Wilcken-Bergmann, B, Müller-Hill, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1994
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC308472/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7971270/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.21.4395
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