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The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid.

The X-ray structure of a GCN4 DNA complex (1) shows, that specific DNA binding of the GCN4 basic region is mediated by a complicated network of base pair and DNA backbone contacts. According to the X-ray structure, alanine -14 of the basic region of GCN4 (we define the first leucine of the leucine z...

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Bibliografische gegevens
Hoofdauteurs: Suckow, M, von Wilcken-Bergmann, B, Müller-Hill, B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC309468/
https://ncbi.nlm.nih.gov/pubmed/8502548
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