The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid.
The X-ray structure of a GCN4 DNA complex (1) shows, that specific DNA binding of the GCN4 basic region is mediated by a complicated network of base pair and DNA backbone contacts. According to the X-ray structure, alanine -14 of the basic region of GCN4 (we define the first leucine of the leucine z...
Na minha lista:
| Udgivet i: | Nucleic Acids Res |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1993
|
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8502548/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.9.2081 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|