Route to three-dimensional fragments using diversity-oriented synthesis

Fragment-based drug discovery (FBDD) has proven to be an effective means of producing high-quality chemical ligands as starting points for drug-discovery pursuits. The increasing number of clinical candidate drugs developed using FBDD approaches is a testament of the efficacy of this approach. The s...

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Bibliographische Detailangaben
Hauptverfasser: Hung, Alvin W., Ramek, Alex, Wang, Yikai, Kaya, Taner, Wilson, J. Anthony, Clemons, Paul A., Young, Damian W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084099/
https://ncbi.nlm.nih.gov/pubmed/21482811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015271108
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