Creation and manipulation of common functional groups en route to a skeletally diverse chemical library

We have developed an efficient strategy to a skeletally diverse chemical library, which entailed a sequence of enyne cycloisomerization, [4 + 2] cycloaddition, alkene dihydroxylation, and diol carbamylation. Using this approach, only 16 readily available building blocks were needed to produce a repr...

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Bibliographic Details
Main Authors: Cui, Jiayue, Hao, Jason, Ulanovskaya, Olesya A., Dundas, Joseph, Liang, Jie, Kozmin, Sergey A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084086/
https://ncbi.nlm.nih.gov/pubmed/21383124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015253108
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