Design, synthesis, and biological evaluation of a biyouyanagin compound library

Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can...

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Main Authors: Nicolaou, K. C., Sanchini, Silvano, Sarlah, David, Lu, Gang, Wu, T. Robert, Nomura, Daniel K., Cravatt, Benjamin F., Cubitt, Beatrice, de la Torre, Juan C., Hessell, Ann J., Burton, Dennis R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084107/
https://ncbi.nlm.nih.gov/pubmed/21245351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015258108
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