Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β

[Image: see text] Traditional fragment-based drug discovery (FBDD) relies heavily on structural analysis of the hits bound to their targets. Herein, we present a complementary approach based on diversity-oriented synthesis (DOS). A DOS-based fragment collection was able to produce initial hit compou...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wang, Yikai, Wach, Jean-Yves, Sheehan, Patrick, Zhong, Cheng, Zhan, Chenyang, Harris, Richard, Almo, Steven C., Bishop, Joshua, Haggarty, Stephen J., Ramek, Alexander, Berry, Kayla N., O’Herin, Conor, Koehler, Angela N., Hung, Alvin W., Young, Damian W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018862/
https://ncbi.nlm.nih.gov/pubmed/27660690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00230
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