Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune responses to HIV Gag p24 within 3G9 antibody to DEC205 (“DEC-HIV Gag p24”), an uptake receptor on dendritic cells, to nontargeted protein, w...

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Autori principali: Flynn, Barbara J., Kastenmüller, Kathrin, Wille-Reece, Ulrike, Tomaras, Georgia D., Alam, Munir, Lindsay, Ross W., Salazar, Andres M., Perdiguero, Beatriz, Gomez, Carmen E., Wagner, Ralf, Esteban, Mariano, Park, Chae G., Trumpfheller, Christine, Keler, Tibor, Pantaleo, Giuseppe, Steinman, Ralph M., Seder, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084061/
https://ncbi.nlm.nih.gov/pubmed/21467219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103869108
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