Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

The success of a non-live vaccine requires improved formulation and adjuvant selection to generate robust T cell immunity following immunization. Here, using protein linked to a TLR7/8 agonist (conjugate vaccine), we investigated the functional properties of vaccine formulation, the cytokines, and t...

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Detalhes bibliográficos
Main Authors: Kastenmüller, Kathrin, Wille-Reece, Ulrike, Lindsay, Ross W.B., Trager, Lauren R., Darrah, Patricia A., Flynn, Barbara J., Becker, Maria R., Udey, Mark C., Clausen, Björn E., Igyarto, Botond Z., Kaplan, Daniel H., Kastenmüller, Wolfgang, Germain, Ronald N., Seder, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083762/
https://ncbi.nlm.nih.gov/pubmed/21540549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45416
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