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Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles
Complexity and the presence of stereogenic centers have been correlated with success as compounds transition from discovery through the clinic. Here we describe the synthesis of a library of pyran-containing macrocycles with a high degree of structural complexity and up to five stereogenic centers....
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084052/ https://ncbi.nlm.nih.gov/pubmed/21383141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015255108 |
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