Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain

AIM: To establish a novel, sensitive and high-throughput gelatinolytic assay to define new inhibitors and compare domain deletion mutants of gelatinase B/matrix metalloproteinase (MMP)-9. METHODS: Fluorogenic Dye-quenched (DQ)™-gelatin was used as a substrate and biochemical parameters (substrate an...

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Autors principals: Vandooren, Jennifer, Geurts, Nathalie, Martens, Erik, den Steen, Philippe E Van, Jonghe, Steven De, Herdewijn, Piet, Opdenakker, Ghislain
Format: Artigo
Idioma:Inglês
Publicat: Baishideng Publishing Group Co., Limited 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083944/
https://ncbi.nlm.nih.gov/pubmed/21537473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4331/wjbc.v2.i1.14
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