CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice

Expression of the transmembrane glycoprotein CD98 (encoded by SLC3A2) is increased in intestinal inflammatory conditions, such as inflammatory bowel disease (IBD), and in various carcinomas, yet its pathogenetic role remains unknown. By generating gain- and loss-of-function mouse models with genetic...

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Detalhes bibliográficos
Main Authors: Nguyen, Hang Thi Thu, Dalmasso, Guillaume, Torkvist, Leif, Halfvarson, Jonas, Yan, Yutao, Laroui, Hamed, Shmerling, Doron, Tallone, Tiziano, D’Amato, Mauro, Sitaraman, Shanthi V., Merlin, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083801/
https://ncbi.nlm.nih.gov/pubmed/21490400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44631
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