Loss of TFF1 is associated with activation of NF-κB–mediated inflammation and gastric neoplasia in mice and humans

Trefoil factor 1 (TFF1) is a tumor suppressor gene that encodes a peptide belonging to the trefoil factor family of protease-resistant peptides. Although TFF1 expression is frequently lost in gastric carcinomas, the tumorigenic pathways this affects have not been determined. Here we show that Tff1-k...

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Detalhes bibliográficos
Main Authors: Soutto, Mohammed, Belkhiri, Abbes, Piazuelo, M. Blanca, Schneider, Barbara G., Peng, DunFa, Jiang, Aixiang, Washington, M. Kay, Kokoye, Yasin, Crowe, Sheila E., Zaika, Alexander, Correa, Pelayo, Peek, Richard M., El-Rifai, Wael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083788/
https://ncbi.nlm.nih.gov/pubmed/21490402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43922
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