Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

TFF1, a secreted protein, plays an essential role in keeping the integrity of gastric mucosa and its barrier function. Loss of TFF1 expression in the TFF1-knockout (KO) mouse leads to a pro-inflammatory phenotype with a cascade of gastric lesions that include low-grade dysplasia, high-grade dysplasi...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Soutto, Mohammed, Chen, Zheng, Bhat, Ajaz A., Wang, Lihong, Zhu, Shoumin, Gomaa, Ahmed, Bates, Andreia, Bhat, Nadeem S., Peng, Dunfa, Belkhiri, Abbes, Piazuelo, M. Blanca, Washington, M. Kay, Steven, Xi Chen, Peek, Richard, El-Rifai, Wael
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620282/
https://ncbi.nlm.nih.gov/pubmed/31292446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11011-4
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