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Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood disorders, including anxiety and depression. However, therapeutic compounds that interact with TrkB receptors have been...

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Autors principals: Cazorla, Maxime, Prémont, Joël, Mann, Andre, Girard, Nicolas, Kellendonk, Christoph, Rognan, Didier
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083767/
https://ncbi.nlm.nih.gov/pubmed/21505263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43992
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