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Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood disorders, including anxiety and depression. However, therapeutic compounds that interact with TrkB receptors have been...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083767/ https://ncbi.nlm.nih.gov/pubmed/21505263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43992 |
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