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Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway in the yeast Saccharomyces cerevisiae is mediated by two membrane-bound ubiquitin ligases, Doa10 and Hrd1. These enzymes are found in distinct multiprotein complexes that allow them to recognize and target a variety of substrates f...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jo, Youngah, Sguigna, Peter V., DeBose-Boyd, Russell A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083207/
https://ncbi.nlm.nih.gov/pubmed/21343306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211326
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