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MAPK Scaffold IQGAP1 Binds the EGF Receptor and Modulates Its Activation
Cellular responses produced by EGF are mediated through the receptor (EGFR) and by various enzymes and scaffolds. Recent studies document IQGAP1 as a scaffold for the MAPK cascade, binding directly to B-Raf, MEK, and ERK and regulating their activation in response to EGF. We previously showed that E...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083173/ https://ncbi.nlm.nih.gov/pubmed/21349850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227694 |
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