MAPK Scaffold IQGAP1 Binds the EGF Receptor and Modulates Its Activation

Cellular responses produced by EGF are mediated through the receptor (EGFR) and by various enzymes and scaffolds. Recent studies document IQGAP1 as a scaffold for the MAPK cascade, binding directly to B-Raf, MEK, and ERK and regulating their activation in response to EGF. We previously showed that E...

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Detalhes bibliográficos
Main Authors: McNulty, Dean E., Li, Zhigang, White, Colin D., Sacks, David B., Annan, Roland S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083173/
https://ncbi.nlm.nih.gov/pubmed/21349850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227694
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