MAPK Scaffold IQGAP1 Binds the EGF Receptor and Modulates Its Activation

Cellular responses produced by EGF are mediated through the receptor (EGFR) and by various enzymes and scaffolds. Recent studies document IQGAP1 as a scaffold for the MAPK cascade, binding directly to B-Raf, MEK, and ERK and regulating their activation in response to EGF. We previously showed that E...

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Bibliographische Detailangaben
Hauptverfasser: McNulty, Dean E., Li, Zhigang, White, Colin D., Sacks, David B., Annan, Roland S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083173/
https://ncbi.nlm.nih.gov/pubmed/21349850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227694
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