Crystal Structure of Toxoplasma gondii Porphobilinogen Synthase: INSIGHTS ON OCTAMERIC STRUCTURE AND PORPHOBILINOGEN FORMATION

Porphobilinogen synthase (PBGS) is essential for heme biosynthesis, but the enzyme of the protozoan parasite Toxoplasma gondii (TgPBGS) differs from that of its human host in several important respects, including subcellular localization, metal ion dependence, and quaternary structural dynamics. We...

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Bibliografske podrobnosti
Main Authors: Jaffe, Eileen K., Shanmugam, Dhanasekaran, Gardberg, Anna, Dieterich, Shellie, Sankaran, Banumathi, Stewart, Lance J., Myler, Peter J., Roos, David S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083160/
https://ncbi.nlm.nih.gov/pubmed/21383008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226225
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