Crystal Structure of Toxoplasma gondii Porphobilinogen Synthase: INSIGHTS ON OCTAMERIC STRUCTURE AND PORPHOBILINOGEN FORMATION

Porphobilinogen synthase (PBGS) is essential for heme biosynthesis, but the enzyme of the protozoan parasite Toxoplasma gondii (TgPBGS) differs from that of its human host in several important respects, including subcellular localization, metal ion dependence, and quaternary structural dynamics. We...

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Hlavní autoři: Jaffe, Eileen K., Shanmugam, Dhanasekaran, Gardberg, Anna, Dieterich, Shellie, Sankaran, Banumathi, Stewart, Lance J., Myler, Peter J., Roos, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083160/
https://ncbi.nlm.nih.gov/pubmed/21383008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226225
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