Crystal Structure of Toxoplasma gondii Porphobilinogen Synthase: INSIGHTS ON OCTAMERIC STRUCTURE AND PORPHOBILINOGEN FORMATION

Porphobilinogen synthase (PBGS) is essential for heme biosynthesis, but the enzyme of the protozoan parasite Toxoplasma gondii (TgPBGS) differs from that of its human host in several important respects, including subcellular localization, metal ion dependence, and quaternary structural dynamics. We...

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Bibliografiska uppgifter
Huvudupphovsmän: Jaffe, Eileen K., Shanmugam, Dhanasekaran, Gardberg, Anna, Dieterich, Shellie, Sankaran, Banumathi, Stewart, Lance J., Myler, Peter J., Roos, David S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083160/
https://ncbi.nlm.nih.gov/pubmed/21383008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226225
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