S-Adenosylmethionine Decreases Lipopolysaccharide-Induced Phosphodiesterase 4B2 and Attenuates Tumor Necrosis Factor Expression via cAMP/Protein Kinase A Pathway

S-Adenosylmethionine (SAM) treatment has anti-inflammatory, cytoprotective effects against endotoxin-induced organ injury. An important component of the anti-inflammatory action of SAM involves down-regulation of the lipopolysaccharide (LPS)-induced transcriptional induction of tumor necrosis factor...

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Bibliographische Detailangaben
Hauptverfasser: Gobejishvili, Leila, Avila, Diana V., Barker, David F., Ghare, Smita, Henderson, David, Brock, Guy N., Kirpich, Irina A., Joshi-Barve, Swati, Mokshagundam, Sri Prakash L., McClain, Craig J., Barve, Shirish
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2011
Schlagworte:
Inflammation, Immunopharmacology, and Asthma
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083110/
https://ncbi.nlm.nih.gov/pubmed/21266552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.174268
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