Probing the Multifactorial Basis of Plasmodium falciparum Quinine Resistance: Evidence for a Strain-Specific Contribution of the Sodium-Proton Exchanger PfNHE

Quinine (QN) continues to be an important treatment option for severe malaria, however resistance to this drug has emerged in field isolates of the etiologic agent Plasmodium falciparum. Quantitative trait loci investigations of QN resistance have mapped three loci of this complex trait. Two coincid...

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Main Authors: Nkrumah, Louis J., Riegelhaupt, Paul M., Moura, Pedro, Johnson, David J., Patel, Jigar, Hayton, Karen, Ferdig, Michael T., Wellems, Thomas E., Akabas, Myles H., Fidock, David A.
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082771/
https://ncbi.nlm.nih.gov/pubmed/19428659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2009.01.011
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