Quinine Treatment Selects the pfnhe–1 ms4760–1 Polymorphism in Malian Patients with Falciparum Malaria

Background. The mechanism of Plasmodium falciparum resistance to quinine is not known. In vitro quantitative trait loci mapping suggests involvement of a predicted P. falciparum sodium–hydrogen exchanger (pfnhe–1) on chromosome 13. Methods. We conducted prospective quinine efficacy studies in 2 vill...

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Hauptverfasser: Kone, Aminatou, Mu, Jianbing, Maiga, Hamma, Beavogui, Abdoul H., Yattara, Omar, Sagara, Issaka, Tekete, Mamadou M., Traore, Oumar B., Dara, Antoine, Dama, Souleymane, Diallo, Nouhoum, Kodio, Aly, Traoré, Aliou, Björkman, Anders, Gil, Jose P., Doumbo, Ogobara K., Wellems, Thomas E., Djimde, Abdoulaye A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
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Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537444/
https://ncbi.nlm.nih.gov/pubmed/23162138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis691
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