Quinine Treatment Selects the pfnhe–1 ms4760–1 Polymorphism in Malian Patients with Falciparum Malaria

Background. The mechanism of Plasmodium falciparum resistance to quinine is not known. In vitro quantitative trait loci mapping suggests involvement of a predicted P. falciparum sodium–hydrogen exchanger (pfnhe–1) on chromosome 13. Methods. We conducted prospective quinine efficacy studies in 2 vill...

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Detalhes bibliográficos
Main Authors: Kone, Aminatou, Mu, Jianbing, Maiga, Hamma, Beavogui, Abdoul H., Yattara, Omar, Sagara, Issaka, Tekete, Mamadou M., Traore, Oumar B., Dara, Antoine, Dama, Souleymane, Diallo, Nouhoum, Kodio, Aly, Traoré, Aliou, Björkman, Anders, Gil, Jose P., Doumbo, Ogobara K., Wellems, Thomas E., Djimde, Abdoulaye A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537444/
https://ncbi.nlm.nih.gov/pubmed/23162138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis691
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