Agonist-Directed Desensitization of the β(2)-Adrenergic Receptor

The β(2)-adrenergic receptor (β(2)AR) agonists with reduced tachyphylaxis may offer new therapeutic agents with improved tolerance profile. However, receptor desensitization assays are often inferred at the single signaling molecule level, thus ligand-directed desensitization is poorly understood. H...

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Bibliographic Details
Main Authors: Goral, Vasiliy, Jin, Yan, Sun, Haiyan, Ferrie, Ann M., Wu, Qi, Fang, Ye
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082563/
https://ncbi.nlm.nih.gov/pubmed/21541288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019282
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