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An Ultra-High Throughput Cell-Based Screen for Wee1 Degradation Inhibitors
The tyrosine kinase Wee1 is part of a key cellular sensing mechanism that signals completion of DNA replication, ensuring proper timing of entry into mitosis. Wee1 acts as an inhibitor of mitotic entry by phosphorylating cyclin-dependent kinase CDK1. Wee1 activity is mainly regulated at the protein...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082437/ https://ncbi.nlm.nih.gov/pubmed/20660794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057110375848 |
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