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Characterization and Comparison of Disulfide Linkages and Scrambling Patterns in Therapeutic Monoclonal Antibodies - Using LC-MS with Electron Transfer Dissociation
The disulfides in three monoclonal antibodies (mAb), the anti-HER2, anti-CD11a, and GLP-1 with IgG4-Fc fusion protein, were completely mapped by LC-MS with the combination of ETD and CID fragmentation. In addition to mapping the 4 inter- and 12 intra-chain disulfides (total 16), the identification o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082428/ https://ncbi.nlm.nih.gov/pubmed/21428412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac200128d |
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