The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA.

The La (SS-B) autoimmune antigen is an RNA-binding protein that is present in both nucleus and cytoplasm of eukaryotic cells. The spectrum of RNAs that interact with the La antigen includes species which also bind to the interferon-inducible protein kinase PKR. We have investigated whether the La an...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Xiao, Q, Sharp, T V, Jeffrey, I W, James, M C, Pruijn, G J, van Venrooij, W J, Clemens, M J
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1994
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC308203/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7518914/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.13.2512
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