The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA.

The La (SS-B) autoimmune antigen is an RNA-binding protein that is present in both nucleus and cytoplasm of eukaryotic cells. The spectrum of RNAs that interact with the La antigen includes species which also bind to the interferon-inducible protein kinase PKR. We have investigated whether the La an...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Xiao, Q, Sharp, T V, Jeffrey, I W, James, M C, Pruijn, G J, van Venrooij, W J, Clemens, M J
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 1994
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC308203/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7518914/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.13.2512
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