Structure, Energetics and Dynamics of Binding Coactivator Peptide to Human Retinoid X Receptor Alpha Ligand Binding Domain Complex with 9-cis-Retinoic Acid

Retinoid X receptors (RXRs) are ligand-dependent nuclear receptors, which are activated by the potent agonist 9-cis retinoic acid (9cRA). 9cRA binds to the ligand binding domain (LBD) of RXRs, and recruits coactivator proteins for gene transcription. Using isothermal titration calorimetry, the bindi...

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Detalhes bibliográficos
Main Authors: Xia, Gang, Boerma, LeeAnn J, Cox, Bryan D, Qiu, Cheng, Kang, Sebyung, Smith, Craig D, Renfrow, Matthew B, Muccio, Donald D
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081989/
https://ncbi.nlm.nih.gov/pubmed/21049972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101288y
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