Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

A high-resolution structure of a ligand-bound, soluble form of human monoglyceride lipase (MGL) is presented. The structure highlights a novel conformation of the regulatory lid-domain present in the lipase family as well as the binding mode of a pharmaceutically relevant reversible inhibitor. Analy...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Schalk-Hihi, Céline, Schubert, Carsten, Alexander, Richard, Bayoumy, Shariff, Clemente, Jose C, Deckman, Ingrid, DesJarlais, Renee L, Dzordzorme, Keli C, Flores, Christopher M, Grasberger, Bruce, Kranz, James K, Lewandowski, Frank, Liu, Li, Ma, Hongchang, Maguire, Diane, Macielag, Mark J, McDonnell, Mark E, Mezzasalma Haarlander, Tara, Miller, Robyn, Milligan, Cindy, Reynolds, Charles, Kuo, Lawrence C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2011
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081545/
https://ncbi.nlm.nih.gov/pubmed/21308848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.596
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi