Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

A high-resolution structure of a ligand-bound, soluble form of human monoglyceride lipase (MGL) is presented. The structure highlights a novel conformation of the regulatory lid-domain present in the lipase family as well as the binding mode of a pharmaceutically relevant reversible inhibitor. Analy...

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Главные авторы: Schalk-Hihi, Céline, Schubert, Carsten, Alexander, Richard, Bayoumy, Shariff, Clemente, Jose C, Deckman, Ingrid, DesJarlais, Renee L, Dzordzorme, Keli C, Flores, Christopher M, Grasberger, Bruce, Kranz, James K, Lewandowski, Frank, Liu, Li, Ma, Hongchang, Maguire, Diane, Macielag, Mark J, McDonnell, Mark E, Mezzasalma Haarlander, Tara, Miller, Robyn, Milligan, Cindy, Reynolds, Charles, Kuo, Lawrence C
Формат: Artigo
Язык:Inglês
Опубликовано: Wiley Subscription Services, Inc., A Wiley Company 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081545/
https://ncbi.nlm.nih.gov/pubmed/21308848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.596
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