Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

Aberrant activation of matrix metalloproteinases (MMPs) is a common feature of pathological cascades observed in diverse disorders, such as cancer, fibrosis, immune dysregulation, and neurodegenerative diseases. MMP-9, in particular, is highly dynamically regulated in several pathological processes....

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Publicado en:J Biol Chem
Autores principales: Scannevin, Robert H., Alexander, Richard, Haarlander, Tara Mezzasalma, Burke, Sharon L., Singer, Monica, Huo, Cuifen, Zhang, Yue-Mei, Maguire, Diane, Spurlino, John, Deckman, Ingrid, Carroll, Karen I., Lewandowski, Frank, Devine, Eric, Dzordzorme, Keli, Tounge, Brett, Milligan, Cindy, Bayoumy, Shariff, Williams, Robyn, Schalk-Hihi, Celine, Leonard, Kristi, Jackson, Paul, Todd, Matthew, Kuo, Lawrence C., Rhodes, Kenneth J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663893/
https://ncbi.nlm.nih.gov/pubmed/28860188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806075
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