IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation

AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and the hydrophobic motif (S473) by the mammalian target of rapamycin complex 2 (mTORC2). We recently observed that phosphorylation of the AKT hydrophobic motif was dramatica...

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Main Authors: Xie, Xiaoduo, Zhang, Denghong, Zhao, Bin, Lu, Min-Kan, You, Ming, Condorelli, Gianluigi, Wang, Cun-Yu, Guan, Kun-Liang
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081021/
https://ncbi.nlm.nih.gov/pubmed/21464307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016132108
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