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IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation
AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and the hydrophobic motif (S473) by the mammalian target of rapamycin complex 2 (mTORC2). We recently observed that phosphorylation of the AKT hydrophobic motif was dramatica...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081021/ https://ncbi.nlm.nih.gov/pubmed/21464307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016132108 |
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