p53 Hypersensitivity Is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (TGCT) Cells to Cisplatin

Consistent with the excellent clinical results in testicular germ cell tumors (TGCT), most cell lines derived from this cancer show an exquisite sensitivity to Cisplatin. It is well accepted that the high susceptibility of TGCT cells to apoptosis plays a central role in this hypersensitive phenotype...

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Detalhes bibliográficos
Main Authors: Gutekunst, Matthias, Oren, Moshe, Weilbacher, Andrea, Dengler, Michael A., Markwardt, Christiane, Thomale, Jürgen, Aulitzky, Walter E., van der Kuip, Heiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080918/
https://ncbi.nlm.nih.gov/pubmed/21532991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019198
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