RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. A...

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Hlavní autoři: Weilbacher, A, Gutekunst, M, Oren, M, Aulitzky, W E, van der Kuip, H
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123078/
https://ncbi.nlm.nih.gov/pubmed/25010984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.284
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