RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. A...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Weilbacher, A, Gutekunst, M, Oren, M, Aulitzky, W E, van der Kuip, H
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2014
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123078/
https://ncbi.nlm.nih.gov/pubmed/25010984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.284
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller