RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. A...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Weilbacher, A, Gutekunst, M, Oren, M, Aulitzky, W E, van der Kuip, H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123078/
https://ncbi.nlm.nih.gov/pubmed/25010984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.284
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker