Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present report describes functional and structural analys...

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Main Authors: Alagramam, Kumar N., Goodyear, Richard J., Geng, Ruishuang, Furness, David N., van Aken, Alexander F. J., Marcotti, Walter, Kros, Corné J., Richardson, Guy P.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080917/
https://ncbi.nlm.nih.gov/pubmed/21532990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019183
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