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Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present report describes functional and structural analys...

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Autors principals: Alagramam, Kumar N., Goodyear, Richard J., Geng, Ruishuang, Furness, David N., van Aken, Alexander F. J., Marcotti, Walter, Kros, Corné J., Richardson, Guy P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080917/
https://ncbi.nlm.nih.gov/pubmed/21532990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019183
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