A West Nile Virus DNA Vaccine Utilizing a Modified Promoter Induces Neutralizing Antibody in Younger and Older Healthy Adults in a Phase I Clinical Trial

Background. West Nile virus (WNV) is a flavivirus that causes meningitis and encephalitis. There are no licensed vaccines to prevent WNV in humans. The safety and immunogenicity of a first-generation WNV DNA vaccine was demonstrated in a clinical trial and a similar DNA vaccine has been licensed for...

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Main Authors: Ledgerwood, Julie E., Pierson, Theodore C., Hubka, Sarah A., Desai, Niraj, Rucker, Steve, Gordon, Ingelise J., Enama, Mary E., Nelson, Steevenson, Nason, Martha, Gu, Wenjuan, Bundrant, Nikkida, Koup, Richard A., Bailer, Robert T., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080891/
https://ncbi.nlm.nih.gov/pubmed/21398392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir054
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