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A West Nile Virus DNA Vaccine Utilizing a Modified Promoter Induces Neutralizing Antibody in Younger and Older Healthy Adults in a Phase I Clinical Trial

Background. West Nile virus (WNV) is a flavivirus that causes meningitis and encephalitis. There are no licensed vaccines to prevent WNV in humans. The safety and immunogenicity of a first-generation WNV DNA vaccine was demonstrated in a clinical trial and a similar DNA vaccine has been licensed for...

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Hlavní autoři: Ledgerwood, Julie E., Pierson, Theodore C., Hubka, Sarah A., Desai, Niraj, Rucker, Steve, Gordon, Ingelise J., Enama, Mary E., Nelson, Steevenson, Nason, Martha, Gu, Wenjuan, Bundrant, Nikkida, Koup, Richard A., Bailer, Robert T., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080891/
https://ncbi.nlm.nih.gov/pubmed/21398392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir054
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