Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII). CDK9 activity is regulated by protein phosphatase-1 (PP1) which was previously shown to dephosphorylate CDK9 Thr186. Here, we analyzed the effect...

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Bibliographic Details
Main Authors: Ammosova, Tatiana, Obukhov, Yuri, Kotelkin, Alexander, Breuer, Denitra, Beullens, Monique, Gordeuk, Victor R., Bollen, Mathieu, Nekhai, Sergei
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080879/
https://ncbi.nlm.nih.gov/pubmed/21533037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018985
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