Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription

CDK9/cyclin T1, a key enzyme in HIV-1 transcription, is negatively regulated by 7SK RNA and the HEXIM1 protein. Dephosphorylation of CDK9 on Thr(186) by protein phosphatase 1 (PP1) in stress-induced cells or by protein phosphatase M1A in normally growing cells activates CDK9. Our previous studies sh...

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Detalhes bibliográficos
Main Authors: Ammosova, Tatiana, Yedavalli, Venkat R. K., Niu, Xiaomei, Jerebtsova, Marina, Van Eynde, Aleyde, Beullens, Monique, Bollen, Mathieu, Jeang, Kuan-Teh, Nekhai, Sergei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030381/
https://ncbi.nlm.nih.gov/pubmed/21098020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196493
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