Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer

BACKGROUND: Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. MET...

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Main Authors: Ooki, Akira, Yamashita, Keishi, Kikuchi, Shiro, Sakuramoto, Shinichi, Katada, Natsuya, Waraya, Mina, Kawamata, Hiroshi, Nishimiya, Hiroshi, Nakamura, Kazunori, Watanabe, Masahiko
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080833/
https://ncbi.nlm.nih.gov/pubmed/21466710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-122
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