RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells

BACKGROUND: Sensitivity of cancer cells to recombinant arginine deiminase (rADI) depends on expression of argininosuccinate synthetase (AS), a rate-limiting enzyme in synthesis of arginine from citrulline. To understand the efficiency of RNA interfering of AS in sensitizing the resistant cancer cell...

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Главные авторы: Wu, Fe-Lin Lin, Liang, Yu-Fen, Chang, Yuan-Chen, Yo, Hao-Hsin, Wei, Ming-Feng, Shen, Li-Jiuan
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2011
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080799/
https://ncbi.nlm.nih.gov/pubmed/21453546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-25
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