Depletion of Arginine by Recombinant Arginine Deiminase Induces nNOS-Activated Neurotoxicity in Neuroblastoma Cells

The abnormal regulation of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) is associated with neurodegenerative disorders. Recombinant arginine deiminase (rADI) is a selective NO modulator of iNOS and eNOS in endothelial cells, and it also exhibits neuroprotective ac...

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Detalhes bibliográficos
Main Authors: Lin, Shan-Erh, Wu, Fe-Lin Lin, Wei, Ming-Feng, Shen, Li-Jiuan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122191/
https://ncbi.nlm.nih.gov/pubmed/25126568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/589424
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