Macrophage IL-12p70 Signaling Prevents HSV-1–Induced CNS Autoimmunity Triggered by Autoaggressive CD4(+) Tregs

PURPOSE. CD4(+)CD25(+)FoxP3(+) naturally occurring regulatory T cells (Tregs) maintain self-tolerance and function to suppress overly exuberant immune responses. However, it is unclear whether innate immune cells modulate Treg function. Here the authors examined the role of innate immunity in lympho...

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Detalhes bibliográficos
Main Authors: Mott, Kevin R., Gate, David, Zandian, Mandana, Allen, Sariah J., Rajasagi, Naveen Kumar, van Rooijen, Nico, Chen, Shuang, Arditi, Moshe, Rouse, Barry T., Flavell, Richard A., Town, Terrence, Ghiasi, Homayon
Formato: Artigo
Idioma:Inglês
Publicado em: Association for Research in Vision and Ophthalmology, Inc. 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080735/
https://ncbi.nlm.nih.gov/pubmed/21220560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6536
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