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In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen experienced cells

The T lymphocyte pool can be sub-divided into naïve (Tn), effector memory (Tem), and central memory (Tcm) T cells. In this study, we characterized in vitro short-term cultured anti-tumor human T lymphocytes generated by lentiviral transduction with an anti-tumor antigen TCR vector. Within two weeks...

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Main Authors: Yang, Shicheng, Gattinoni, Luca, Liu, Fang, Ji, Yun, Yu, Zhiya, Restifo, Nicholas P., Rosenberg, Steven A., Morgan, Richard A.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080434/
https://ncbi.nlm.nih.gov/pubmed/21305379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-0977-7
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